From Gates



Access BCF upon Level 3 alert:

Limited to non-IBC Academia Sinica researchers, please follow the rules below during the pandemic situation to access BCF:
1. All non-IBC researchers must sign-in and sign-out and follow all mask/cleaning protocols.
2. Non-IBC researchers must work when a member of the facility staff is present (9:00 ~ 18:00).
3. No more than one non-IBC researcher should be present in a given facility at a time.
4. Please check and reserve "疫情期間預約進入生化所 402 室 (BCF)登記簿" before reserve the instrument time.
5. Biacore users may start to run desorb and shutdown at 9:00 AM on the next day. Do not reserve Biacore instrument time on Friday.

Check BCF Charges Update.

Check BCF Courses.


Welcome to BCF homepage at

title BCF History

The Biophysics Core Facility (BCF) of the Scientific Instrument Center, Academia Sinica, is located in Room 402 in the Institute of Biological Chemistry. Previously known as Molecular Characterization Core, the facility, in operation since 2008, is the home of several state-of-art instruments, providing technical support for facility users in terms of training, scheduling, workshops, user certification, trouble shooting and instrument maintenance. To learn about BCF's training courses, please visit our Courses website.

BCF currently houses the following instruments: analytical ultracentrifuge (Beckman XL-I), surface plasmon resonance biosensors (GE Biacore T200), bio-layer interferometer (ForteBIO Octet RED96,), isothermal titration calorimeter (GE MicroCal iTC200), differential scanning calorimeter (TA Nano DSC III, Malvern MicroCal VP-Capillary DSC), dynamic and static light scattering spectrometer (Malvern Zetasizer Nano) and capillary isoelectric focusing platform (ProteinSimple NanoPRO 1000); in addition, on sharing basis, a differential scanning calorimeter (GE MicroCal VP-DSC) with Institute of Physics, a surface plasmon resonance biosensor (Biacore T100) with Institute of Plant and Microbial Biology and an analytical ultracentrifuge (Beckman AUC XL-A) with Institute of Biological Chemistry. In combination of results from each instrument, researchers gain insights into the thermodynamics, kinetics and structural information for interactions of biological molecules.

BCF staff:
Manager: Dr. Jao, Shu-Chuan Chris 饒淑娟 博士
Assistant: Mr. Chen, Kun-Hung 陳昆宏 先生
Tel: 2785-5696 x4024

BCF User Committee members (Apr. 2020-):
Dr. Chen, Pei-Yeh Rita (Chairman, Institute of Biological Chemistry)
Dr. Chu, Hsiu-An (Institute of Plant and Microbial Biology)
Dr. Ho, Cheng-Hsun (Agricultural Biotechnology Research Center)
Dr. Hsia, Kuo-Chiang (Institute of Molecular Biology)
Dr. Huang, Jen-Tse Joseph (Institute of Chemistry)
Dr. Li, Tsung-Lin (Genomics Research Center)
Dr. Mou, Yun (Institute of BioMedical Sciences)


stopped-flow CD  AUC  iTC  Zeta  DSC  T100  AutoLab